/An Early Mark Blog/

October 2018

The Challenges and Opportunities of Prospective Longitudinal Studies

By |2018-11-06T02:53:18+00:00October 24th, 2018|

The Challenges and Opportunities of Prospective Longitudinal Studies Is it possible to accelerate the future? What is exciting about working in the field of clinical molecular diagnostics is its promise of real impact on human health. Yet the path from biomarker discovery to an FDA-approved test in general use is a long and painstaking process: [...]

Why use circulating tumor methylated DNA (ctmDNA) to detect disease?

By |2018-11-06T02:54:55+00:00October 22nd, 2018|

Why use circulating tumor methylated DNA (ctmDNA) to detect disease? Circulating tumor DNA (ctDNA) isn’t abundant enough for subtle signals from circulating DNA History and context of cell-free DNA and its role in cancer In 1949 Mandel and Matais discovered cell-free DNA in plasma in a French publication and in 1965 (seventeen years [...]

Looking for new circulating biomarker signals with new technology

By |2018-10-21T11:43:51+00:00October 21st, 2018|

Looking for new circulating biomarker signals with new technology Note: A version of this post was previously published on The Next Generation Technologist blog. Cell-free DNA is an attractive analyte For those not too familiar with cell-free DNA, this is DNA shed from natural (or unnatural) cell death and typically is cleared from [...]

An Early Mark: Announcing the Singlera Genomics Blog

By |2018-11-06T02:56:48+00:00October 21st, 2018|

An Early Mark: Announcing the Singlera Genomics Blog Singlera Genomics has been established with the most elusive of goals: to detect disease early, through a gene signature that can be as easy as a blood test. Through analysis of circulating methylated DNA markers in the bloodstream rather than specific DNA mutations, the numbers [...]

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