/Dale Yuzuki

About Dale Yuzuki

A sales and marketing professional in the life sciences research-tools area, Dale currently is employed by Singlera Genomics as an Assoc Director of Business Development. He will help Singlera forge partnerships in using their novel methylation haplotype from cell-free DNA to examine blood-based assays for early disease diagnostics development. He also represents Singlera at tradeshows and other events. For additional biographical information, please see my LinkedIn profile here: http://www.linkedin.com/in/daleyuzuki and also find me on Twitter @DaleYuzuki.

Optimum plasma sample collection and handling for cell-free DNA liquid biopsies

By |2018-12-13T15:38:52+00:00December 13th, 2018|

Optimum plasma sample collection and handling for cell-free DNA liquid biopsies A recent publication indicates the best way to preserve intact cell-free DNA for any minimally-invasive genomic assay Liquid biopsy, whether examining cell-free DNA or circulating tumor cells (CTCs), is a very promising approach for non-invasive cancer management. In particular, cell-free DNA approaches in plasma [...]

Singlera ASHG Presentation now available

By |2018-12-05T13:34:08+00:00December 5th, 2018|

Screen capture from Dr. Gore's video presentation of the Singlera early-detection technology. A video presentation by Dr. Athurva Gore, Assoc. Director of Bioinformatics Singlera Genomics, is now available. The title of his talk is "Circulating tumor DNA methylation haplotypes in plasma can detect cancer four years prior to conventional diagnosis", and is the [...]

The four fundamentals of early warning systems

By |2018-11-26T03:15:55+00:00November 26th, 2018|

Hurricane Katrina as seen from space The four fundamentals of early warning systems A way to look at early cancer detection A hurricane afflicts damage across Florida. Wildfires rage through California. A deadly typhoon afflicts central Japan after weeks of flooding. These natural disasters occur with disturbing regularity. An individual's health can also [...]

Current screening approaches for early cancer detection

By |2018-11-20T05:47:54+00:00November 20th, 2018|

Mammography, a common cancer screening test Current screening approaches for early cancer detection The American Cancer Society screening recommendations and a thought experiment A recent article by a Stanford professor (and Andreessen Horowitz venture fund general partner) Vijay Pande in The Scientific American, entitled "How to Engineer Biology", subtitled 'Billion-dollar bridges rarely fail—whereas [...]

Single molecule detection of ctmDNA

By |2018-11-12T06:59:36+00:00November 12th, 2018|

Singlera detects single molecules of ctmDNA Single molecule detection of ctmDNA The reason why early detection biomarkers for cancer is not a trivial task First, second and third-generation sequencing First-generation sequencing (also known as Sanger sequencing, or dideoxy-terminator sequencing) was the technology used for the Human Genome Project, and remains a workhorse and [...]

Obtain many circulating biomarkers broadly, or a few biomarkers deeply?

By |2018-11-08T08:03:07+00:00November 8th, 2018|

A ribbon model of molecules of protein p53 binding to a strand of DNA.         Obtain many circulating biomarkers broadly, or a few biomarkers deeply? Can you have it all? At the recent Society for Neuroscience, Abcam sponsored a workshop entitled "Biomarkers of Neuroinflammation in Parkinson’s Disease" where Dr. Nicole [...]

Why isn’t cancer prevention a higher priority?

By |2018-11-05T06:19:48+00:00November 5th, 2018|

Why isn't cancer prevention a higher priority? Cancer death rates could be drastically reduced Cancer is the second leading cause of death worldwide. In a recent issue of the journal Science (Sept 28 2018, Vol 361 Issue 6409 page 1317, "Cancer Prevention: Molecular and epidemiologic consensus" Song M and Tomasetti C et al. ref 1) [...]

What if circulating tumor methylated DNA from brain cancer could be detected?

By |2018-11-06T02:51:21+00:00October 29th, 2018|

A group of CAT scans of the human brain What if circulating tumor methylated DNA from brain cancer could be detected? Can ctmDNA be an early detection tool for glioblastoma multiforme? Gliblastoma Multiforme is a terrible form of brain cancer. With a reported 5-year survival rate of only 4.4%, at just the 3-year [...]

Circulating Biomarkers: the Internet of Biology

By |2018-11-06T02:52:33+00:00October 26th, 2018|

Circulating Biomarkers: the Internet of Biology Signals within the remarkable circulatory system A few weeks ago learning about a new San Diego CA company called Cardea Biosciences they described a novel functionalized graphene biosensor with the tagline, ‘Powering the Internet of Biology’. This is a powerful metaphor – the Internet is seen as a ‘fourth [...]

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