For colorectal cancer, the only good screening test is one that is taken Tests for detecting hidden (“occult”) blood in stool is widely available Screenshot from USPSTF CRC screening video We have discussed before the challenge of raising colorectal cancer screening rates, and the fact that there are many options in addition to [...]
Calculating the odds of undetected colorectal cancer In a group of 200 adults aged 50 to 75, what are the chances of finding someone with undetected CRC? Many take chances with their health, in particular CRC screening The unscreened population for colorectal cancer is large. According to Exact Sciences (the manufacturer of the [...]
Raising colorectal cancer screening rates is a tough task An accurate blood-based test to detect colorectal cancer is the key to lowering the mortality from this devastating disease Screenshot from USPSTF CRC screening video In 2018 there were an estimated 140,250 new cases of colorectal cancer (CRC), and 50,630 estimated deaths, [...]
Why is stool such a difficult non-invasive starting material for early colorectal cancer detection? Fecal Immunohistochemistry Tests (FIT) and guiac-based Fecal Occult Blood tests (gFOBT) are inexpensive and widely available tests for colorectal cancer screening. However there remains a clear need for an accurate blood-based colorectal screening test. A stool collection vial for colorectal [...]
Blood collection tubes prior to centrifuging The difference between plasma and serum for cell-free DNA liquid biopsies Important pre-analytical sampling considerations for DNA and protein biomarker work Using plasma or serum for analysis of novel biomarkers for the early detection of cancer is an effort that spans decades. Thanks to its minimally-invasive nature, [...]
The power of methylation haplotypes How NGS technology informed biology and now transforming cancer diagnostics with an epigenomics Cambrian Explosion Finding a cell-free cancer signal is like finding a needle in a haystack... Of the 28 million CpG residues in the human genome, 60% to 80% of them are methylated at the 5’ [...]
Five Phases of Biomarker Development for Early Detection of Cancer Where are the retrospective studies? Collecting samples About two decades ago was an exciting time in biology, and optimism reached a peak with the first draft of the Human Genome Project announced in 2000 (“A revolution in preventing, diagnosing, treating, and curing disease” [...]
Screen capture from Dr. Gore's video presentation of the Singlera early-detection technology. Singlera ASHG Presentation now available A video presentation by Dr. Athurva Gore, Assoc. Director of Bioinformatics Singlera Genomics, is now available. The title of his talk is "Circulating tumor DNA methylation haplotypes in plasma can detect cancer four years prior to [...]
Hurricane Katrina as seen from space The four fundamentals of early warning systems A way to look at early cancer detection A hurricane afflicts damage across Florida. Wildfires rage through California. A deadly typhoon afflicts central Japan after weeks of flooding. These natural disasters occur with disturbing regularity. An individual's health can also [...]
Mammography, a common cancer screening test Current screening approaches for early cancer detection The American Cancer Society screening recommendations and a thought experiment A recent article by a Stanford professor (and Andreessen Horowitz venture fund general partner) Vijay Pande in The Scientific American, entitled "How to Engineer Biology", subtitled 'Billion-dollar bridges rarely fail—whereas [...]
