Scientific Posters and Presentations

The two scientific posters presented at the recent 2018 American Society for Human Genetics conference are available. Titled "Circulating tumor DNA methylation haplotypes in plasma can detect cancer four years prior to conventional diagnosis" and "Circulating tumor DNA methylation haplotypes in plasma can accurately detect early-stage colorectal cancer and advanced adenomas in a single blinded study".

In addition, we have made available a video presentation by Dr. Athurva Gore, Assoc. Director of Bioinformatics Singlera Genomics. The title of his talk is "Circulating tumor DNA methylation haplotypes in plasma can detect cancer four years prior to conventional diagnosis".

Both posters and presentation can be accessed after website registration with your name and email address.

Publications of note

1. Guo S. et al Nat Genet. 2017 Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. doi: 10.1038/ng.3805
2. BLUEPRINT consortium. Nat Biotechnol. 2016 Quantitative comparison of DNA methylation assays for
   biomarker development and clinical applications. doi: 10.1038/nbt.3605
3. Gole J. et al Nat Biotechnol. 2013 Massively parallel polymerase cloning and genome sequencing of
   single cells using nanoliter microwells. doi: 10.1038/nbt.2720
4. Ruiz S. et al. Proc Natl Acad Sci U S A. 2012 Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. doi: 10.1073/pnas.1202352109
5. Diep D. et al Nature Meth 2012 Library-free methylation sequencing with bisulfite padlock probes. doi: 10.1038/nmeth.1871
6. Yamaguchi S. et al Nature 2012 Tet1 controls meiosis by regulating meiotic gene expression https://www.ncbi.nlm.nih.gov/pubmed/23151479
7. Gore A. et al Nature 2011 Somatic coding mutations in human induced pluripotent stem cells. doi: 10.1038/nature09805
8. Shoemaker R. et al. Genome Res. 2010. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. doi: 10.1101/gr.104695.109
9. Deng J. et al. Nat Biotechnol. 2009. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. doi: 10.1038/nbt.1530

GenomeWeb Articles

Singlera Genomics Presents Data on Cell-Free DNA Methylation Test for Early Cancer Detection (Paywall) Oct 18, 2018

Singlera to Use $60M Funding to Support Launch of IVDs, Research Into Very Early Detection of Cancer (Paywall) Apr 5, 2018

UCSD Methylation Haplotype Method Tracks cfDNA Origin; Singlera to Commercialize (Paywall) Mar 8, 2017

Singlera, Fudan University Partner on Cancer Biomarker Project Jul 18, 2016

Singlera Genomics, Yale Partner on NIPT Clinical Trial Jan 25, 2016

General Singlera Company Information

Access a descriptive flyer about Singlera Genomics here.